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2013 Fiscal Year Final Research Report

Elucidation of mechanisms of epithelial-mesenchymal interactions in epithelial repair processes during acute lung injury and its clinical application

Research Project

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Project/Area Number 23792081
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Emergency medicine
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

HASHIMOTO Soshi  京都府立医科大学, 医学(系)研究科(研究院), 助教 (60515279)

Project Period (FY) 2011 – 2012
Keywords急性肺損傷 / 急性呼吸窮迫症候群 / 人工呼吸 / 上皮間葉転換
Research Abstract

We have established a mouse model of acute lung injury by unilateral intratracheal instillation of hydrochloric acid. In lung histological analyses, we observed increased inflammatory cell infiltration, edema formation, and hemorrhages at 24 hours after instillation, and the development of pulmonary fibrosis at 14 days after instillation. However, we were not able to identify the mechanisms of epithelial-mesenchymal interactions in epithelial repair processes during acute lung injury. In the meantime, we found out recombinant thrombomodulin tended to prevent the development of lung fibrosis in histological analysis, suggesting that its effect might contribute to involve epithelial repair processes during acute lung injury.

  • Research Products

    (5 results)

All 2013 2012

All Journal Article (3 results) Presentation (2 results)

  • [Journal Article] 急性呼吸促迫症候群に対する人工呼吸管理法の単施設・10年間の変遷2013

    • Author(s)
      橋本壮志,志馬伸朗,橋本悟
    • Journal Title

      日本集中治療医学会雑誌

      Volume: 20 Pages: 287-8

  • [Journal Article] Evaluation of semi-quantitative scoring of Gram staining or semi-quantitative culture for the diagnosis of ventilator-associated pneumonia : a retrospective comparison with quantitative culture2013

    • Author(s)
      Soshi Hashimoto, Nobuaki Shime
    • Journal Title

      Journal of Intensive Care

      Volume: 1 Pages: 2

  • [Journal Article] Successful treatment of severe asthma-associated plastic bronchitis with extracorporeal membrane oxygenation2012

    • Author(s)
      Momoka Tonan, Soshi Hashimoto, Akio Kimura, Hiroki Matsuyama, Hiromi Kinose, Maiko Sawada, Nobuaki Shime, Natsuko Tokuhira, Yuko Kato, Masayuki Sasaki, Kunihiko Tsuchiya, Satoshi Higaki, Tadaki Oomae, Satoru Hashimoto
    • Journal Title

      J Anesth

      Volume: 26(2) Pages: 265-8

  • [Presentation] Ten Year Trend Of Ventilator Settings For Acute Lung Injury : A Single Institute Investigation2012

    • Author(s)
      Soshi Hashimoto, Nobuaki Shime, Satoru Hashimoto
    • Organizer
      2012 ATS International Conference
    • Place of Presentation
      San Francisco, California
    • Year and Date
      2012-05-20
  • [Presentation] シンポジウム3 VAPをなくすための総合戦略.下気道検体の定量培養結果は直接鏡検/定性培養にて予測できるか?2012

    • Author(s)
      橋本壮志,志馬伸朗,溝部俊樹,橋本悟,佐和貞治
    • Organizer
      第39回日本集中治療医学会学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2012-02-29

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Published: 2015-06-25  

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