Immunoanalysis of severe septic patients in the elderly and therapeutic potential of IL-15

2012 Fiscal Year Final Research Report

• Project/Area Number: 23792088
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Emergency medicine
• Research Institution: Tokai University
• Principal Investigator: INOUE Shigeaki 東海大学, 創造科学技術研究機構, 講師 (30582209)
• Project Period (FY): 2011 – 2012
• Keywords: 高齢者 / 敗血症 / 免疫 / IL-15

Research Abstract

Reduction of immunocompetent T cells followed byprolonged lymphopenia may be associated with poor prognosis in elderly septic patients.IL-15 reactivates exhausted T cells and improves survival of sepsis in aged mice.

Research Products

• [Journal Article] Reduction of immunocompetent T cells followed by prolonged lymphopenia in severe sepsis in the elderly (2013)
  • Author(s): Inoue S, Suzuki-Utsunomiya K, Okada Y, Iida Y, Taira T, Miura N, Tsuji T, Yamagiwa T, Morita S, Chiba T, Sato T, Inokuchi S
  • Journal Title: Crit Care Med Volume: 41 Pages: 810-819
  • Peer Reviewed
• [Presentation] 高齢者敗血症における末梢血単核球の免疫機能解析 (2012)
  • Author(s): 井上茂亮 鈴木恭子 小森由香子 井口貞樹
  • Organizer: 第39回日本集中治療医学会学術集会
  • Place of Presentation: 千葉 幕張メッセ
  • Year and Date: 20120228-0301
• [Presentation] (2012)
  • Author(s): Inoue S, Suzuki-Utsumoniya K, Komori Y, Sato T, Inokuchi S
  • Organizer: 日本外科代謝栄養学会第49回学術集会日韓合同シンポジウム講演
  • Place of Presentation: 千葉
  • Year and Date: 2012-07-06