2012 Fiscal Year Final Research Report
To elucidate the pathophysiology of sepsis-associated organ dysfunction involving the Ang/Tie2 signaling pathway
| Project/Area Number |
23792091
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | Nippon Medical School |
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Principal Investigator |
WADA Takeshi 日本医科大学, 医学部, 助教 (30455646)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 集中治療医学 / 急性期医学 |
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| Research Abstract |
The aim of this study was to elucidate the pathophysiology of sepsis-associated organ dysfunction involving the Ang/Tie2 signaling pathway and to establish a new therapeutic strategy for treating critical illnesses, such as sepsis, severe trauma and post-cardiac arrest syndrome. I examined the relationship between organ dysfunction associated with critical illness and angiogenic factors, including VEGF, Ang and their receptors and found that Ang2 plays a pivotal role in the development of organ dysfunction due to coagulofibrinolytic abnormalities. The findings of this study have been presented at six domestic and four international conferences and have also been published by four peerreview articles.
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