2012 Fiscal Year Final Research Report
The novel study model of cleft lip established by the interaction between genetic and environmental factors in mice
| Project/Area Number |
23792098
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 口唇裂 / 口蓋裂 / 先天異常 / 遺伝要因 / 環境要因 / マウス / 顔面発生 |
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| Research Abstract |
As a result of keeping a pregnant mouse carrying the gene mutation of Msx1 under low oxygen environment for a certain period, mutant embryos exhibited the statistically higher frequency of cleft lip than wild-type embryos. Our results clearly demonstrated a concrete example of gene-environmental multifactorial threshold model, which has been theoretically advocated to explain a cause behind congenital anomalies. Our newly established experimental system would be of value to reveal the mechanisms ofcleft lip and palate in the future.
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Research Products
(1 results)
