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2012 Fiscal Year Final Research Report

Mechanisms of extra-molar development by Bcl11b mutation

Research Project

  • PDF
Project/Area Number 23792100
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Morphological basic dentistry
Research InstitutionNiigata University

Principal Investigator

KATSURAGI Yoshinori  新潟大学, 医歯学系, 助教 (60401759)

Project Period (FY) 2011 – 2012
Keywords口腔解剖学(含組織学・発生学)
Research Abstract

We have showed that Bcl11b mice exhibited extra-molarsand hypoplastic maxillary incisors. In incisors of this mutant, hypoplasia of laCL whichcontains stem cells of ameloblast lineage, impaired proliferation of TA cells, and reducednumber of LRC were observed. Our data suggest that Bcl11b is not directly related to theFGF and Shh signaling but is intrinsic to ameloblast progenitors and possibly stem cells.

  • Research Products

    (9 results)

All 2013 2012 2011 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (6 results)

  • [Journal Article] Cell of origin in radiation-induced premalignant thymocytes with differentiation capability in mice conditionally losing one Bcl11b allele2013

    • Author(s)
      Go R, Hirose S, Katsuragi Y, Obata M, Abe M, Mishima Y, Sakimura K, Kominami R.
    • Journal Title

      Cancer Science

      Volume: (Epub ahead of print)

    • DOI

      DOI:10.1111/cas.12193

    • Peer Reviewed
  • [Journal Article] Impairment in differentiation and cell cycle of thymocytes by loss of a Bcl11b tumor supp essor allele that contributes to leukemogenesis2012

    • Author(s)
      Go R, Takizawa K, Hirose S, Katsuragi Y, Aoyagi Y, Mishima Y, Kominami R.
    • Journal Title

      Leukemia Research

      Volume: 36 Pages: 1035-1040

    • DOI

      DOI:10.1016/j.leukres.2012.04.028

    • Peer Reviewed
  • [Journal Article] Bcl11b transcription factor plays a role in the maintenance of the ameloblast-progenitors in mouse adult maxillary incisors

    • Author(s)
      Katsuragi Y, Anraku J, Nakatomi M, Ida-Yonemochi H, Obata M, Mishima Y, Sakuraba Y, Gondo Y, Kodama Y, Nishikawa A, Takagi R, Ohshima H, Kominami R.
    • Journal Title

      Mechanisms of Development

      Volume: (in press)

    • DOI

      DOI:10.1016/j.mod.2013.05.002

    • Peer Reviewed
  • [Presentation] Bcl11b transcription factor plays a role in the homeostasis of the ameloblast-progenitors in mouse adult maxillary incisors2012

    • Author(s)
      Katsuragi Y, Anraku J, Nakatomi M, Ida-Yonemochi H, Mishima Y, Obata M, Sakuraba Y, Gondo Y, Takagi R, Oshima H, Kominami R.
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡市
    • Year and Date
      2012-12-12
  • [Presentation] 木南凌放射線照射後の腸上皮におけるBcl11bの働き2012

    • Author(s)
      葛城美徳、坂牧僚、小幡美貴、三嶋行雄、大塚健介
    • Organizer
      第55回日本放射線影響学会
    • Place of Presentation
      仙台市
    • Year and Date
      2012-09-07
  • [Presentation] Bcl11b transcription factor controls the formation and maintenance of the ameloblast-lineage cells in mouse adult maxillary incisor2011

    • Author(s)
      Katsuragi Y, Anraku J, Nakatomi M, Ida-Yonemochi H, Mishima Y, Sakuraba Y, Gondo Y, Takagi R, Oshima H, Kominami R.
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      横浜市
    • Year and Date
      2011-12-13
  • [Presentation] 木南凌Bcl11bの片アリル消失はγ線照射後のマウス小腸上皮幹細胞の増殖を促進する2011

    • Author(s)
      葛城美徳、坂牧僚、小幡美貴、三嶋行雄
    • Organizer
      第54回日本放射線影響学会
    • Place of Presentation
      神戸市
    • Year and Date
      2011-11-18
  • [Presentation] Loss of a Bcl11b allele promotes proliferation of stem cells in the mouse small intestine after γ-irradiation2011

    • Author(s)
      Katsuragi Y, Sakamaki A, Obata M, Mishima Y, Kominami R.
    • Organizer
      ICRR(国際放射線研究連合会議)
    • Place of Presentation
      ワルシャワ(ポーランド)
    • Year and Date
      2011-08-31
  • [Presentation] 木南凌Bcl11bはエナメル芽細胞譜の形成と維持に関与する2011

    • Author(s)
      葛城美徳、安楽純子、中富満城、依田浩子、三嶋行雄、桜庭喜行、権藤洋一、高木律男、大島勇人
    • Organizer
      モロシヌス研究会
    • Place of Presentation
      ホテルベルナティオ(新潟県十日町)
    • Year and Date
      2011-07-08

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Published: 2014-09-25  

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