2013 Fiscal Year Final Research Report
Study on the mechanism of F-spondin/LDL receptor family for hard tissue destruction
| Project/Area Number |
23792103
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
OKA HIROKO 広島大学, 医歯薬保健学研究院(歯), 特任助教 (60452588)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 硬組織破壊 / 歯周組織 / F-spondin / LDL受容体ファミリー |
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| Research Abstract |
We demonstrated that F-spondin downregulated migration and differentiation of precursor osteoclasts partially via one of LDL receptor family, Lrp8. Moreover, our data suggested that LDL receptor family members on precursor osteoclasts, themselves regulated migration and differentiation of precursor osteoclasts independently of F-spondin.
F-spondin-expressed cells maintained osteoclastogenesis by secretory F-spondin and other factors. Also, F-spondin expression on cells affected the expression level of LDL receptor family members on it.
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