2013 Fiscal Year Final Research Report

Study on the mechanism of F-spondin/LDL receptor family for hard tissue destruction

Research Project

Project/Area Number	23792103
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Morphological basic dentistry
Research Institution	Hiroshima University
Principal Investigator	OKA HIROKO 広島大学, 医歯薬保健学研究院(歯), 特任助教 (60452588)
Project Period (FY)	2011 – 2013
Keywords	硬組織破壊 / 歯周組織 / F-spondin / LDL受容体ファミリー
Research Abstract	We demonstrated that F-spondin downregulated migration and differentiation of precursor osteoclasts partially via one of LDL receptor family, Lrp8. Moreover, our data suggested that LDL receptor family members on precursor osteoclasts, themselves regulated migration and differentiation of precursor osteoclasts independently of F-spondin. F-spondin-expressed cells maintained osteoclastogenesis by secretory F-spondin and other factors. Also, F-spondin expression on cells affected the expression level of LDL receptor family members on it.

(3 results)