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2012 Fiscal Year Final Research Report

A study to develop a novel therapeutic/ preventive strategy for oral bacterial infectious diseases based on the obstruction of lipoprotein modification enzymes

Research Project

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Project/Area Number 23792113
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Morphological basic dentistry
Research InstitutionShowa University

Principal Investigator

TAKAFUMI Arimoto  昭和大学, 歯学部, 講師 (60407393)

Project Period (FY) 2011 – 2012
Keywordslipoprotein / prolipoprotein diacylglyceryl transferase / Streptococcus mutans / signal peptidase
Research Abstract

We have been engaged in the work regarding surface lipoprotein on cariogenic bacterium, Streptococcus mutans. Until now, we have identified and functional analyzed lipoproteins related to sugar and amino acid uptake. Moreover, these lipoproteins have been clarified to be modified by lipoprotein modification enzymes, prolipoprotein diacylglyceryl transferase (Lgt) and lipoprotein-specific signal peptidase II (LspA), which is very important for the pysiological function of the lipoproteins. In this study, we identified that lipoprotein OpcC was involved in the acid tolerance which is one of cariogenic properties of S. mutans and demonstrated that the lipoprotein OpcC was under the control of Lgt and LspA in the localization and physiological function. Accumulated evidence and this finding strongly suggest that lipoproteins are definitely related to the pathogenic properties of S. mutans. Furthermore, lipoprotein modification enzymes should be attractive targets to develop a new strategy for prevention and therapeutic against dental caries.

  • Research Products

    (7 results)

All 2013 2012 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (3 results) Remarks (1 results)

  • [Journal Article] Involvement of lipoprotein PpiA of Streptococcus gordonii in evasion of phagocytosis by macrophages2013

    • Author(s)
      Kasei Cho, Takafumi Arimoto, Takeshi Igarashi, Matsuo Yamamoto
    • Journal Title

      Molecular Oral Microbiology

      Volume: (In press)

    • Peer Reviewed
  • [Journal Article] Relationship between CiaRH and Lipoprotein OpcC in the Acid Tolerance of Streptococcus mutans2013

    • Author(s)
      Taniguchi, Makoto; Arimoto, Takafumi; Igarashi, Takeshi
    • Journal Title

      Dental Medicine Research

      Volume: 33 (1) Pages: 2-11

    • Peer Reviewed
  • [Journal Article] Toll-like receptor 2-mediated modulation of growth and functions of regulatory T cells by oralstreptococci2013

    • Author(s)
      Saeki, Ayumi; Segawa, Taku; Abe, Tsugumi; Sugiyama, Masahiro; Arimoto, Takafumi; Hara, Hiroshi; Hasebe, Akira; Ohtani, Makoto; Tanizume, Naoho; Ohuchi, Manabu; Kataoka, Hideo; Kawanami, Masamitsu; Yokoyama, Atsuro; Ken-ichiro
    • Journal Title

      Molecular Oral Microbiology

      Volume: (In press)

    • Peer Reviewed
  • [Presentation] Relationship between lipoprotein PpiA and scavenger receptors in Streptococcus gordonii evasion of phagocytosis2012

    • Author(s)
      K. Chou, T. Arimoto, M. Taniguchi, T. Ando, M. Yamamoto, T. Igarashi
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎
    • Year and Date
      20120327-29
  • [Presentation] Modulation of growth and functions of CD4+CD25+Foxp3+ regulatory T cells by oral streptococci2012

    • Author(s)
      A. Saeki, T. Segawa, H. Kataoka, A. Hasebe, T. Arimoto, ・・・K. Shibata
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎
    • Year and Date
      20120327-29
  • [Presentation] Roles of lipoproteins in clearance of oral streptococci2012

    • Author(s)
      T. Segawa, A. Hasebe, A. Saeki, H. Kataoka, T. Arimoto, ・・・K. Shibata
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎
    • Year and Date
      20120327-29
  • [Remarks]

    • URL

      http://www.showa-u.ac.jp/sch/dent/major/dbisei/index.html

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Published: 2014-09-25  

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