2012 Fiscal Year Final Research Report

Molecular mechanism for regulation of cancer Epithelial-mesenchymal transition in bone microenvironment

Research Project

Project/Area Number	23792122
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Functional basic dentistry
Research Institution	Osaka University
Principal Investigator	TANAKA Soichi 大阪大学, 大学院・歯学研究科, 助教 (20548200)
Project Period (FY)	2011 – 2012
Keywords	骨微小環境 / 上皮間葉転換(EMT) / Snail / USP45 / ユビキチン化 / 脱ユビキチン化 / ビスホスホネート
Research Abstract	Clinical study has shown that breast cancer patients are improved overall survival by Bisphosphonate (ZOL). We investigated whether ZOL is involved in Epithelial-mesenchymal transition (EMT) in bone. We showed bone environment promotes EMT in breast cancer cells. Moreover, ZOL inhibits EMT in bone via stimulation of EMT inducing factor Snail degradation by preventing its de-ubiquitination by USP45, leading to the suppression of secondary metastases from bone.

(2 results)