2012 Fiscal Year Final Research Report
Regulatory mechanism of actin-ring formation through Wnt5a-Ror2 signaling pathway in osteoclasts
| Project/Area Number |
23792134
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional basic dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 破骨細胞 / 骨吸収 / 極性化 / Wnt5a / Ror2 |
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| Research Abstract |
Reorganization of actin cytoskeleton and formation of actin rings in osteoclasts are necessary for bone-resorbing activity. Ror2, a receptor of Wnt5a, was expressed in osteoclasts. Ror2 deficient osteoclasts failed to form actin rings. Furthermore, we revealed that activation of Rho via Daam2 was required for actin ring formation downstream of Ror2.
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[Journal Article] Nishita M, Marumo K, Martin TJ, Minami Y, Takahashi NWnt5a-Ror2 signaling betweenosteoblast-lineage cells and osteoclast precursors enhancesosteoclastgenesis.2012
Author(s)
Maeda K, Kobayashi Y, Udagawa N, Uehara S, Ishihara A, Mizoguchi T, Kikuchi Y, Takada I, Kato S, Kani S
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Journal Title
Nat. Med.
Volume: Vol. 18
Pages: 405-412
DOI
Peer Reviewed
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[Journal Article] Polarized osteoclasts put marks tartrate-resistant acid phosphatase on dentin slices; A simple method for identifying polarized osteoclasts.2011
Author(s)
Nakayama T, Mizoguchi T, Uehara S, Yamashita T, Kawahara I, Kobayashi Y, Moriyama Y, Kurihara S, Sahara N, Ozawa H,Udagawa N, Takahashi N
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Journal Title
Bone
Volume: Vol. 49
Pages: 1331-1339
DOI
Peer Reviewed
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