2013 Fiscal Year Final Research Report
Complement-mediated immunotherapy to the Oral Squamous Cell Carcinoma with Cetuximab
| Project/Area Number |
23792148
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Nagoya City University |
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Principal Investigator |
IMAI MASAKI 名古屋市立大学, 医学(系)研究科(研究院), 講師 (30440936)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 口腔癌 / 抗体 |
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| Research Abstract |
To conserve both form and function in the oral area, effective and selective drugs against oral cancer will be required. We focused on Cetuximab, that is indicated for the treatment of patients with epidermal growth factor receptor (EGFR)-expressing cancer. Complement deposition (C3) on HSC4 (human oral squamous cell carcinomas cell line) by incubation with Cetuximab and human serum was slightly enhanced. On the other hands, complement inhibitors expressed on tumor cells provide a hindrance to the therapeutic efficacy of some monoclonal antibodies. We investigated a strategy to amplify complement activation on tumor cells and overwhelm complement inhibitor function. Complement deposition and lysis of HSC4 cells by incubation with Cetuximab and human serum was enhanced in the presence of CR2-Fc. CR2-Fc enhances the therapeutic efficacy of antibody therapy and may provide particular benefits under conditions of limiting antibody concentration or low tumor antigen density.
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[Journal Article] Complement C5A Antagonist Treatment Improves the Acute Circulatory and Inflammatory Consequences of Experimental Cardiac Tamponade2013
Author(s)
Erces D, Nógrády M, Nagy E, Varga G, Vass A, Süveges G, Imai M, Okada N, Okada H, Boros M, Kaszaki J
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Journal Title
Crit. Care. Med.
Volume: 41
Pages: e344-e351
DOI
Peer Reviewed
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[Journal Article] Anti-C5a complementary peptide ameliorates acute peritoneal injuries induced by neutralization of Crry and CD592013
Author(s)
Mizuno T, Mizuno M, Imai M, Suzuki Y, Kushida M, Noda Y, Maruyama S, Okada H, Okada N, Matsuo S, Ito Y
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Journal Title
Am J Physiol Renal Physiol
Volume: 305
Pages: F1603-1616
DOI
Peer Reviewed
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[Journal Article] Inflammatory Activation after Experimental Cardiac Tamponade2013
Author(s)
Vass A, Süveges G, Erces D, Nógrády M, Varga G, Földesi I, Futakuchi M, Imai M, Okada N, Okada H, Boros M, Kaszaki J
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Journal Title
Eur Surg Res
Volume: 51
Pages: 1-13
DOI
Peer Reviewed
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[Journal Article] Endothelin Receptor Antagonist Attenuates Oxidative Stress in Neonatal Sepsis Model2012
Author(s)
Goto T, Hussein MH, Kato S, Daoud GA, Kato T, Sugiura T, Kakita H, Nobata M, Kamei M, Mizuno H, Imai M, Ito T, Kato I, Suzuki S, Okada N, Togari H, Okada H
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Journal Title
Pediatric Research
Volume: 72
Pages: 600-605
DOI
Peer Reviewed
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[Journal Article] Increased levels of cytokines and high-mobility group box 1 are associated with the development of severe pneumonia, but not acute encephalopathy, in 2009 H1N1 influenza-infected children2011
Author(s)
Ito Y, Torii Y, Ohta R, Imai M, Hara S, Kawano Y, Matsubayashi T, Inui A, Yoshikawa T, Nishimura N, Ozaki T, Morishima T, Kimura H
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Journal Title
Cytokine
Volume: 56
Pages: 180-187
DOI
Peer Reviewed
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[Presentation] C5a is a target to prevent peritoneal tissue damage in acute peritoneal injury in rats2012
Author(s)
Mizuno T, Mizuno M, Imai M, Suzuki Y, Kushida M, Yamada K, Noda Y, Maruyama S, Okada H, Okada N, Matsuo S, Ito Y
Organizer
XXIV International Complement Workshop
Place of Presentation
Crete, Greece
Year and Date
20121010-15
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[Presentation] 急性腹膜生涯に対するアンチセンスC5aペプチドの治療効果2012
Author(s)
水野智博,水野正司,櫛田真由,野田幸裕,山田清文,今井優樹,岡田秀親,岡田則子,丸山彰一,松尾清一,伊藤恭彦
Organizer
第49回補体シンポジウム
Place of Presentation
大阪成人病センター(大阪)
Year and Date
20120824-25
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