2012 Fiscal Year Final Research Report
Investigate of the quorum sensing by which cardiovascular disease are influenced by periodontopathic bacterium infection
| Project/Area Number |
23792149
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
OKINAGA Toshinori 九州歯科大学, 歯学科・感染分子生物学分野, 助教 (60582773)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 免疫 / 感染 / 炎症 |
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| Research Abstract |
Atherosclerosis shows a chronic inflammatory process initiated by the recruitment of monocyte-derived macrophage into the sub-endothelial arterial space. Chronic bacterial infections, including periodontitis, are associated with an increased risk of coronary heart diseases. Periodontitis is a chronic inflammatory disease infected with a gram-negative periodontopathic bacterium, such as Aggregatibacter actinomycetemcomitans. We previously reported that infection of murine macrophages in vitro with the periodontopathic bacterium A. actinomycetemcomitans induced cell cycle arrest during phase G1. In the present study, we investigated the role of suppressor of cytokine signaling (SOCS) in induction of the cell cycle in A. actinomycetemcomitans-infected macrophages. Our results indicate that intrinsic SOCS-3 normally activates the expression of cell cycle associated protein, while overexpression of SOCS-3 down-regulates p21 expression in infected RAW 264.7 cells, suggesting that SOCS-3 has dexterous effects to regulate the cell cycle in macrophages infected with periodontopathic bacteria.
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