Strategic fusion of nuclear proteins dynamics of the malignant tumor and nuclear medicine

2013 Fiscal Year Final Research Report

• Project/Area Number: 23792150
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Kyushu Dental College
• Principal Investigator: KITO Shinji 九州歯科大学, 歯学部, 助教 (80347682)
• Project Period (FY): 2011 – 2013
• Keywords: nucleolin / nucleophosmin / アポトーシス / 18F-FDG-PET-CT / 辺縁性歯周炎 / 根尖性歯周囲炎 / 生理的集積 / 舌

Research Abstract

Dynamic alteration of nucleolin and AgNORs proteins in UV-induced SCC-25 and HSG cells were examined using Western blot analysis and histocytochemistry methods. Dynamic alteration of nucleolin and AgNORs proteins are observed. With regard to nuclear medicine, A significant correlation was found between the size of bone resorption area by periapical or periodontal inflammation and standardized uptake value with the highest point (SUVmax) of 18F-FDG accumulations. 18F-FDG accumulations could exactly reflect the extent of the dental inflammation. 18F-FDG-PET-positive areas, excluding primary tumors, included the front intrinsic muscles of the tongue (89.0%), upper and lower marginal parts of the orbicularis oris muscle (64.6%), sublingual glands, palatine tonsil, pharyngeal tonsil, and lingual tonsil. In addition, some areas in the jaws also showed accumulation.

Research Products

• [Journal Article] Criteria and limitations for selecting a sagittal split ramus osteotomy for patients with skeletal mandibular prognathism and open bite (2013)
  • Author(s): Y oshioka I, Tanaka T, Habu M, Oda M, Kodama M, Kokuryo S, Kito S, Wakasugi-Sato N, Matsumoto-Takeda S, Seta Y, Fukudome Y, Tominaga K, Sakoda S, Morimoto Y
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Volume: 115 Pages: 455-465
• [Journal Article] Variety and complexity of ^<18>F-FDG accumulations in oral cavity of patients with oral cancers (2013)
  • Author(s): Kito S, Koga H, Kodama M, Habu M, Kokuryo S, Yamamoto N, Oda M, Nishino T, Zhang M, Matsuo K, Wakasugi-Sato N, Matsumoto-Takeda S, Seta Y, Yoshiga D, Kaneuji T, Nogami S, Yoshioka I, Yamashita Y, Tanaka T, Miyamoto I, Kitamura C, Tominaga K, Morimoto Y
  • Journal Title: Dentomaxillofac Radiol Volume: 42
  • DOI: 10.1259/dmfr.20130014
• [Journal Article] Occurrence of silk stitch abscess after surgery in patients with oral squamous cell carcinoma (2013)
  • Author(s): Yamamoto N, Yamashita Y, Yoshiga D, Ishikawa A, Matsuo K, Miyamoto I, Oda M, Tanaka T, Kito S, Seta Y, Takahashi T, Koga H, Kenji K, Morimoto Y
  • Journal Title: Med Oral Patol Oral Cir Bucal Volume: 18 Pages: e701-705
  • DOI: 10.4317/medoral.18792
• [Journal Article] Prevalence and imaging characteristics of detectable tonsilloliths on 482 pairs of consecutive CT and panoramic radiographs (2013)
  • Author(s): Oda M, Kito S, Tanaka T, Nishida I, Awano S, Fujita Y, Saeki K, Matsumoto-Takeda S, Wakasugi-Sato N, Habu M, Kokuryo S, Kodama M, Kaneuji T, Yoshiga D, Miyamoto I, Nishimura S, Yamashita Y, Maki K, Tominaga K, Yoshioka I, Ansai T, Morimoto Y
  • Journal Title: BMC Oral Healt Volume: 13 Pages: 54
  • DOI: 10.1186/1472-6831-13-54
• [Journal Article] Identification of peripheral vessels in oral and maxillofacial regions on magnetic resonance angiography obtained using a balanced steady-state free-precession sequence with a time-spatial labeling inversion pulse and using fresh blood imaging (2013)
  • Author(s): Oda M, Tanaka T, Yamashita Y, Kito S, Wakasugi-Sato N, Matsumoto-Takeda S, Nishimura S, Habu M, Kodama M, Uehara M, Kaneuji T, Kokuryo S, Miyamoto I, Yoshiga D, Seta Y, Tominaga K, Yoshioka I, Morimoto Y
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Volume: 116 Pages: 791-797
  • DOI: 10.1016/j.oooo.2013.09.016
• [Journal Article] Reflection of (18)F-FDG accumulation in the evaluation of the extent of periapical or periodontal inflammation (2012)
  • Author(s): Kito S, Koga H, Kodama M, Yamamoto N, Kokuryo S, Habu M, Matsuo K, Nishino T, Kubota K, Muraoka K, Oda M, Wakasugi-Sato N, Matsumoto-Takeda S, Seta Y, TanakaT, Miyamoto I, Yamashita Y, Kitamura C, Nakashima K, Takahashi T, Tominaga K, Morimoto Y
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Volume: 114(6) Pages: e62-9
• [Presentation] 口腔癌の患者における^<18>F-FDGの生理的あるいは非特異的集積 (2013)
  • Author(s): 鬼頭慎司,古賀博文,小田昌史,森本泰宏
  • Organizer: 第53回日本核医学会学術総会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 20131108-10
• [Presentation] ^<18>F-FDG集積は歯性感染症の程度を反映する (2013)
  • Author(s): 鬼頭慎司,田中達朗,小田昌史,若杉(佐藤)奈緒,西村瞬,松本(武田)忍,志岐一欣,森本泰宏
  • Organizer: 第25回日本口腔診断学会・第22回日本口腔内科学会合同学術大会
  • Place of Presentation: 学術総合センター
  • Year and Date: 20130913-14
• [Presentation] 日本歯科放射線学会優秀論文賞受賞講演^18F-FDGの集積は根尖性歯周炎や辺縁性歯周炎の程度を反映する (2013)
  • Author(s): 鬼頭慎司
  • Organizer: 第54回日本歯科放射線学会総会・学術大会
  • Place of Presentation: 福岡県立ももち文化センター
  • Year and Date: 20130601-02
• [Presentation] 口腔癌の患者における^18F-FDGの非特異的集積 (2013)
  • Author(s): 鬼頭慎司,古賀博文,小田昌史,若杉(佐藤)奈緒,田中達朗,志岐一欣,森本泰宏
  • Organizer: 第54回日本歯科放射線学会総会・学術大会
  • Place of Presentation: 福岡県立ももち文化センター
  • Year and Date: 20130601-02
• [Presentation] 歯性感染症の程度の評価における^18F-FDG集積の意義 (2013)
  • Author(s): 鬼頭慎司,古賀博文,小田昌史,若杉(佐藤)奈緒,田中達朗,志岐一欣,森本泰宏
  • Organizer: 第54回九州歯科学会総会
  • Place of Presentation: 九州歯科大学
  • Year and Date: 20130518-19
• [Presentation] 口腔顎顔面領域病変精査の過程で悪性リンパ腫の全身への浸潤が判明した3症例〜^<18>F-FDG-PET-CTの有用性〜 (2013)
  • Author(s): 鬼頭慎司,古賀博文,田中達朗,小田昌史,若杉(佐藤)奈緒,松本(武田)忍,西村瞬,大塚梢,内田朱美,広松辰巳,志岐一欣,森本泰宏
  • Organizer: 日本歯科放射線学会第33回関西・九州合同地方会
  • Place of Presentation: じゅうろくプラザ
  • Year and Date: 2013-12-14
• [Presentation] Usefulness of ^<18>F-FDG accumulation in the evaluation of the extent of dental inflammation (2013)
  • Author(s): Shinji Kito, Masafumi Oda, Nao Wakasugi-Sato, Shinobu Matsumoto-Takeda, Tatsurou Tanaka, Yasuhiro Morimoto
  • Organizer: ASIA-PACIFIC CONFERENCE in FUKUOKA 2013 International Symposium on Oral Education and Research in Kitakyushu
  • Place of Presentation: Kyushu Dental University, Kitakyusyu Japan
  • Year and Date: 2013-01-26
• [Presentation] 歯性感染症における骨吸収の程度と^<18>F-FDG集積との関連性 (2012)
  • Author(s): 鬼頭慎司,古賀博文,小田昌史,森本泰宏
  • Organizer: 第52回日本核医学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 20121011-13
• [Presentation] 根尖性歯周炎あるいは成人性歯周炎における骨吸収の程度と^<18>F-FDG集積との関連性 (2012)
  • Author(s): 鬼頭慎司,古賀博文,田中達朗,小田昌史,志岐一欣,松本(武田)忍,若杉(佐藤)奈緒,大塚梢,林祐樹,滝野正義,広松辰巳,森本泰宏
  • Organizer: 第53回日本歯科放射線学会学術大会
  • Place of Presentation: 盛岡
  • Year and Date: 20120531-0601
• [Presentation] 下顎骨内側に存在する血管の走行を探る—安全なインプラント埋入の為に— (2012)
  • Author(s): 鬼頭慎司,若杉(佐藤)奈緒,小田昌史,松本(武田)忍,田中達朗,小薗孝彰,森本泰宏
  • Organizer: 第72回九州歯科学会総会
  • Place of Presentation: 北九州
  • Year and Date: 20120519-20
• [Presentation] 歯列弓上における^<18>F-FDG高集積には注意が必要である (2012)
  • Author(s): 鬼頭慎司,古賀博文,小田昌史,若杉(佐藤)奈緒,松本(武田)忍,田中達朗,志岐一欣,森本泰宏
  • Organizer: 日本歯科放射線学会第32回関西・九州合同地方会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-09
• [Presentation] 歯科における現在の画像診断とその展望—インプラント・顎関節を中心として— (2012)
  • Author(s): 鬼頭慎司
  • Organizer: 第60回国立病院機構熊本医療センター医歯連携セミナー
  • Place of Presentation: 国立病院機構熊本医療センター熊本
  • Year and Date: 2012-06-21
• [Presentation] 頭頸部悪性腫瘍術後における縫合糸膿瘍の診断に関する検討 (2011)
  • Author(s): 鬼頭慎司,古賀博文,森本泰宏
  • Organizer: 第51回日本核医学会学術総会
  • Place of Presentation: つくば(つくば国際会議場)
  • Year and Date: 20111027-29
• [Presentation] パノラマエックス線画像上で下顎切痕部に不透過像として認められ、様々な部位に存在した異所性石灰化物の3例 (2011)
  • Author(s): 鬼頭慎司,田中達朗,志岐一欣,松本(武田)忍,若杉(佐藤)奈緒,小田昌史,大塚梢,林祐樹,深井康弘,時津高俊,森本泰宏
  • Organizer: 日本歯科放射線学会第16回臨床画像大会
  • Place of Presentation: 新潟(チサンホテル&コンファレンスセンター新潟)
  • Year and Date: 20110930-1002
• [Presentation] A rare case of septic arthritis of the TMJ without malocclusion. The 18^<th> International Congress of DentoMaxilloFacial Radiology (2011)
  • Author(s): Kito S, Tanaka T, Wakasugi-Sato N, Matsumoto-Takeda S, Otsuka K, Oda M , Uchida A, Hiromatsu T, Goya T, Kozono T, Morimoto Y
  • Organizer: 第52回日本歯科放射線学会学術大会共催
  • Place of Presentation: 広島(International Conference Center Hiroshima)
  • Year and Date: 20110525-29
• [Presentation] 両側頬間隙に存在し、軟組織濃度を呈する構造物の1症例 (2011)
  • Author(s): 鬼頭慎司,小田昌史,田中達朗,志岐一欣,松本(武田)忍,大塚梢,林祐樹,滝野正義,若杉(佐藤)奈緒,廣松辰巳,森本泰宏
  • Organizer: 日本歯科放射線学会第31回関西・九州合同地方会
  • Place of Presentation: 名古屋(今池ガスビル7階B会議室)
  • Year and Date: 2011-12-10