The elucidation of the role of'autophagy receptor'in immune mechanism of oral epithelium cells

2012 Fiscal Year Final Research Report

• Project/Area Number: 23792158
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Asahi University
• Principal Investigator: INOMATA Megumi 朝日大学, 歯学部, 助教 (40553798)
• Project Period (FY): 2011 – 2012
• Keywords: 感染防御機構 / オートファジー / Toll 様受容体 (TLR) / ヒト上皮細胞

Research Abstract

Recent findings have shown that autophagy regulates immune mechanism in intestinal epithelial cells. The aim of this study is to investigate whether autophagy is involved in regulation of TLR-dependent immune responses in oral epithelium cells. This studyreveals that the autophagy receptor NDP52 degrades TLR signaling molecules and downregulates TLR-mediated signaling.

Research Products

• [Journal Article] Nuclear dot protein 52, an autophagy-associated protein, regulates Toll-like receptor signaling. (2012)
  • Author(s): Inomata Megumi, and Into Takeshi.
  • Journal Title: J. Oral Biosciences Volume: 54(3) Pages: 151-154
  • URL: http://dx.doi.org/10.1016/j.job.2012.04.004
  • Peer Reviewed
• [Journal Article] Regulation of Toll-like receptor signaling by NDP52-mediated selective autophagy is normally inactivated by A20. (2012)
  • Author(s): Inomata Megumi, Niida Shumpei, ShibataKen-ichiro, and Into Takeshi.
  • Journal Title: Cell Mol. Life Sci. Volume: 69(6) Pages: 963-979
  • DOI: doi:10.1007/s00018-011-0819-y.
  • Peer Reviewed
• [Journal Article] Autophagy in regulation of Toll-like receptor signaling. (2012)
  • Author(s): Into Takeshi, Inomata Megumi, TakayamaEiji, and Takigawa Toshiya.
  • Journal Title: Cell Signal. Volume: 24(6) Pages: 1150-1162
  • DOI: doi:10.1016/j.cellsig.2012.01.020.
  • Peer Reviewed
• [Presentation] Regulation of Toll-like receptor signaling by NDP52-mediated selective autophagy (2012)
  • Author(s): Inomata Megumi and Into Takeshi.
  • Organizer: 6th International Symposium on Autophagy 2012
  • Place of Presentation: Okinawa, JAPAN
  • Year and Date: 20121008-1101
• [Presentation] Regulation of Toll-like receptor signaling by human NDP52-mediated selective autophagy (2012)
  • Author(s): Inomata Megumi, Shibata Ken-ichiro, andInto Takeshi
  • Organizer: The annual meeting of Japanese Society for Immunology
  • Place of Presentation: Chiba, JAPAN
  • Year and Date: 2012-11-27
• [Presentation] 引頭 毅 NDP52 は選択的オートファジーの 誘導によってToll様受容体シグナルを負に制御する (2011)
  • Author(s): 猪俣 恵 、新飯田 俊平、柴田 健一郎
  • Organizer: 第53回歯科基礎医学会学術大会・総会
  • Place of Presentation: 岐阜
  • Year and Date: 2011-10-02
• [Presentation] オートファジーによる Toll 様受容体を介した細胞内シグナル伝達の調節 (2011)
  • Author(s): 猪俣 恵 、引頭 毅
  • Organizer: 第53回歯科基礎医学会学術大会・総会
  • Place of Presentation: 岐阜
  • Year and Date: 2011-09-30
• [Remarks] 朝日大学歯学部口腔感染医療学講座口腔微生物学分野ホームページ
  • URL: http://scw.asahi-u.ac.jp/~bac/index.html