Differential involvement of rostral and caudal Vc neurons in masseter muscle hypersensitivity associated with periodontal inflammation

2012 Fiscal Year Final Research Report

• Project/Area Number: 23792192
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Conservative dentistry
• Research Institution: Nihon University
• Principal Investigator: SHIMIZU Kohei 日本大学, 歯学部, 助教 (10508609)
• Project Period (FY): 2011 – 2012
• Keywords: 歯内療法学

Research Abstract

Present findings indicate that orofacial mechanical allodynia and hyperalgesia occur in the pulpitis stage (3 day), and that hyperalgesia occurs at the late period after periapical periodontitis (6 weeks). These results suggest that pulpitis and periapical periodontitis aredifferentially involved in ectopic orofacial allodynia and hyperalgesia.

Research Products

• [Journal Article] Barry J Sessle and Koichi Iwata. Mechanisms underlying ectopic persistent tooth-pulp pain followingpulpal inflammation. (2013)
  • Author(s): Shingo Matsuura, Kohei Shimizu, Masamichi Shinoda, Kinuyo Ohara, Bunnai Ogiso, Kuniya Honda, Ayano Katagiri
  • Journal Title: PLoS One Volume: 8(1) Pages: e52840
  • Peer Reviewed
• [Journal Article] 咀嚼筋群における筋筋膜痛症候群に起因した非歯原性歯痛と歯内疾患を併発した一例 (2012)
  • Author(s): 清水康平,佐藤隆夫,羽鳥啓介,小林千明,柴崎郁恵,重森葉子,加藤岳詩,橋本一浩,佐藤洋子,澤田朋美,小木曽文内
  • Journal Title: 日本歯科保存学雑誌 Volume: 55巻6号 Pages: 424-431
  • DOI: DOI:10.1371/journal.pone.0052840.
  • Peer Reviewed
• [Journal Article] Hemicrania continua in a patient with concomitant dental disease. (2012)
  • Author(s): Noma N, Kamo H, Shimizu K, Villegas F, Oka S, Imamura Y.
  • Journal Title: J Am Dent Assoc. Volume: 143(10) Pages: 1099-103
  • Peer Reviewed
• [Journal Article] 歯内療法に関連した非歯原性歯痛の一例 (2011)
  • Author(s): 清水康平,小林千明,羽鳥啓介,加藤岳詩,橋本一浩,小木曽文内
  • Journal Title: 日本歯内療法学会雑誌 Volume: 第32巻2号 Pages: 102-107
  • Peer Reviewed
• [Presentation] Mechanisms of orofacial hyperalgesia/allodynia in periapical periodontitis (2012)
  • Author(s): Kohei Shimizu
  • Organizer: 14th International Association for the Study of Pain
  • Place of Presentation: Milan, Italy
  • Year and Date: 2012-08-31
• [Presentation] Toll-likereceptor 4 in the trigeminal sensory neurons is involved in tongue-referred pain following tooth pulp inflammation (2012)
  • Author(s): Kinuyo Ohara
  • Organizer: 14^<th> International Association for theStudy of Pain
  • Place of Presentation: Milan, Italy
  • Year and Date: 2012-08-31
• [Presentation] 慢性根尖性歯周炎に起因した口腔顔面領域における疼痛異常の神経機構 (2012)
  • Author(s): 清水康平
  • Organizer: 第136回日本歯科保存学会
  • Place of Presentation: 沖縄
  • Year and Date: 2012-06-29
• [Presentation] Mechanisms underlying ectopic orofacial allodynia and hyperalgesia following periapical periodontitis (2011)
  • Author(s): Kohei Shimizu
  • Organizer: Society for Neuroscience
  • Place of Presentation: Washington DC,USA
  • Year and Date: 2011-11-15
• [Presentation] Peripheral mechanisms of extraterritorial toothpulp-inflammatory pain (2011)
  • Author(s): Shingo Matsuura
  • Organizer: Society forNeuroscience
  • Place of Presentation: Washington DC, U.S.A.
  • Year and Date: 2011-11-15
• [Presentation] 慢性根尖性歯周炎に起因した口腔顔面領域における疼痛異常の神経機構 (2011)
  • Author(s): 清水康平
  • Organizer: 第16回日本口腔顔面痛学会
  • Place of Presentation: 兵庫
  • Year and Date: 2011-10-09