2013 Fiscal Year Final Research Report
Mechanoregulation of periodontal ligament homeostasis by primary cilia
| Project/Area Number |
23792213
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
KAKU sakiko 新潟大学, 医歯学総合病院, 医員 (60584589)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 歯根膜 / メカニカルストレス / プライマリー・シリア |
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| Research Abstract |
It is evident that mechanical stress contributes the tissue homeostasis of periodontal ligament (PDL). In this study, we explore the distribution and mechanoresponse of primary cilia, a possible mechanosensor in PDL. The anti-acetylated tubulin positive primary cilia were detected in PDL. The primary cilia was preferentially distributed at the cementum side of PDL. The excessive occlulsal loading condition increased the number of primary cilia. These results indicate that the preferential distribution of primary cilia may contribute the site specific mechanoresponse of the PDL.
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