2013 Fiscal Year Final Research Report
Effect of tooth loss on higher brain function in humans
| Project/Area Number |
23792245
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 有床義歯学 / 神経科学 / 脳 / 老化 / ｆＭＲＩ / 無歯顎 |
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| Research Abstract |
Thus, the current study sought to clarify the effect of oral dysfunction on higher brain function in humans. In elderly individuals age 80 and over with 20 or more of their original teeth and edentulous elderly individuals, the effect of masticatory dysfunction resulting from tooth loss on brain function activities was studied using 3T-fMRI.
In all groups, brain activation was noted in the cerebral cortex and more specifically in the motor cortex (Brodmann area 4) and the supplementary motor cortex (Brodmann area 6) as well as in the cerebellum. In the dentulous group and denture-wearing group, brain activation was noted in sensory areas (Brodmann areas 1, 2, and 3) while it was not noted in the edentulous group. In the dentulous group and denture-wearing group, brain activation was noted in the basal ganglia, thalamus, and frontal lobe, i.e. sites of the brain involved in voluntary movement, but it was not noted in the edentulous group.
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