2013 Fiscal Year Final Research Report
Development of cultured cell sheet and nano-coating scaffold for periodontal regeneration
| Project/Area Number |
23792267
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
SHIMOJI Shinji 北海道大学, 歯学研究科(研究院), 助教 (30431373)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 歯周組織再生 / 培養骨髄細胞シート / コラーゲンスキャホールド |
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| Research Abstract |
The purpose of the present study was determine: (1) the novel method of cultured cell sheet using bone marrow cell from F344/Jcl rats' femur; (2) the effectiveness of the cultured bone marrow cell sheet, FGF-2 and collagen sponge scaffold on bone regeneration of rats' calvariae.
The results were as follows: (1) the multilayered osteoblast-like cell sheet was produced by this novel method. The proper culture term made this cell sheet more rigid; (2) the complex of cultured bone marrow cell sheet, FGF-2 and collagen sponge scaffold made large amount of new bone on rats' calvariae.
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