2012 Fiscal Year Final Research Report
Effect s of pro inflammatory cytokines derived from Th-17 cells inhealing of tooth extraction sockets and osseointegration
| Project/Area Number |
23792291
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | Th -17 / IL -17 / 抜歯窩 / インプラント / オッセオインテグレーション |
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| Research Abstract |
The purpose of this study is to examine of the influence of Th -17cell, one of the T-cell subsets (Th-17), and interleukin-17 (IL-17) that is a kind of proinflammatory cytokines produced by Th-17 cells on the healing process following tooth extraction and the osseointegration of dental implants. In vitro study, the effect on osteogenic differentiation of IL -17 using a mouse-derived osteoblastic cell line s, MC3T3-E1 cells (MC3T3-E1) , were analyzed and identified a significant increase in mRNA expression in specific bone marker. However, i n vivo study using rat models, the expression of both Th-17 and IL-17 were rarely observed when we conducted the analysis of the localization of rat extraction socket s.
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