2012 Fiscal Year Final Research Report
The effect of glycosyltransferase GnT-V in the development and progression of oral cancer and evaluation by PET.
| Project/Area Number |
23792307
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
ONODERA Makiko 北海道大学, 大学院・歯学研究科, 専門研究員 (20443963)
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| Project Period (FY) |
2011 – 2012
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| Keywords | GnT-V / PET / HIF-1 |
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| Research Abstract |
The pattern and expression of cell surface sugar chains greatly alter during the carcinogenesis and play important role in tumor progression. To clarify the role of glycosyltrasferase GnT-V in cancer development we examined the expression of GnT-V in the oral cancer association with the PET scan. Both GnT-V mRNA and protein are strongly enhanced in oral cancer compared with normal oral mucosa tissue. In the group with high SUV on FDG-PET and FMISO-PET hypoxia imaging, GnT-V and HIF-1α had tendency to express higher. The expression and function of GnT-V may increase in hypoxia condition. By treatment the human oral squamous cell carcinoma cell line SAS with swainsonine, an inhibitor of N-glycan processing, cell motility was reduced significantly. These results showed that the glycosylation by GnT-V is associate with cell motility and invasion enhancement in oral cancer and related in oral cancer progression.
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