2012 Fiscal Year Final Research Report
The role of PD1+ CD8+ suppressor T cells in nest of oral squamouscell carcinoma
| Project/Area Number |
23792329
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 口腔扁平上皮癌 / 免疫担当細胞 |
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| Research Abstract |
Regulatory T cells are known to suppress tumore immunity in tumor tissues.In recent years, the role of CD8+ T cells has attracted attention in addeition to CD4+ regulator y T cells. Accordingly, the relationship between local CD8+ T ccells in oral squamous cell carcinoma and the pathological condieion thereof was investigated. As a result, it was found that PD -1+ CD8+ T cells, which make up a regulatory lymphocyte subset, were specifically invading inside the cancer cell nest of oral squmous cell carcinoma. This is in contrast to the presence of CD4+ regulatory T cells in the stroma of cancer, and it has been suggested that PD-1+ CD8+ T cells and CD4+ regulatory T cells in the stroma of cancer, and it has been suggested that PD-1+ CD8+ T cells and CD4+ regulatory T cells play different roles regarding the immunosuppression of tumors.
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