2012 Fiscal Year Final Research Report
The mechanism of neuropathic pain and effects of neurotrophic factor in the orofacial area
| Project/Area Number |
23792336
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka University (2012)
Research Institute, Osaka Medical Center for Maternal and Child Health (2011) |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 歯科麻酔学 / 神経因性疼痛 |
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| Research Abstract |
The non-peptidergic fibers in the trigeminal subnucleus caudalis (Vc) decreased after IB4 Saporin injection into the cisterna magna. This study examined formalin-induced pain-related behavior (PRB) in the upper lip and c-Fos expression. In IB4-Saporin-pretreated rats, the formalin-induced PRB was significantly increased compared with those of control rats. The numbers of c-Fos-immunoreactive cells increased compared with those of control rats. In IB4-Saporin-pretreated rats, the formalin-induced PRB after artemin injection in the upper lip was significantly decreased compared with those of saline injection rats.
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