2013 Fiscal Year Final Research Report
The role of glial cells in inflammatory pain and neuropathic pain of mental nerve area.
| Project/Area Number |
23792337
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
KAWANO AKIYO 大阪大学, 歯学部附属病院, 医員 (10570294)
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| Project Period (FY) |
2011 – 2012
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| Keywords | ミクログリア / サテライト細胞 / オトガイ神経 / 神経因性疼痛 / Iba 1 |
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| Research Abstract |
In this study, we used the neuropathic pain model rat which mental nerve was loosely ligated and the hypoalgesia model rat which mental nerve was transected. The behavior of Iba1 immunoreactive cells and satellite cells in the trigeminal ganglion was observed. In both models, the number of Iba1 immunoreactive cells was increased and morphological alteration of satellite cells was observed that was represented by degeneration of cytoplasm and extended spines. After nerve injury the wide space between neuron and satellite cells was observed. Four weeks after injury, this change was sustained in both models, and in addition the cell death of neurons and satellite cells was observed in the hypoalgesia model rat.
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