2013 Fiscal Year Final Research Report
The development of serum diagnostic method applicable for the Japanese using cancer/testis antigens
| Project/Area Number |
23792343
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
DOMAE SHOHEI 岡山大学, 医歯(薬)学総合研究科, 助教 (70397892)
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| Research Collaborator |
ONO Toshro 岡山大学, 自然生命科学研究支援センター, 教授 (50185641)
HANAFUSA Tadashi 岡山大学, 自然生命科学研究支援センター, 准教授 (00228511)
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| Project Period (FY) |
2011 – 2013
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| Keywords | CT抗原 / SEREX / 腫瘍マーカー / 抗体 |
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| Research Abstract |
Cancer/testis (CT) antigens are considered promising target molecules for immunotherapy for patients with various cancers. To identify CT antigens, we performed serological identification of antigens by recombinant expression cloning analysis. We isolated 2 genes with testis specific profiles in the database, including Tektin5 (TEKT5). The humoral immune response of cancer patients against TEKT5 was confirmed. This study indicated that SEREX-defined CCDC62-2, GKAP1 and TEKT5 is immunogenic especially in squamous cell carcinoma of head and neck and demonstrated its potential as a newly diagnostic marker for cancer patients in combination with CT antigens.
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