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2012 Fiscal Year Final Research Report

Functional analysis using genetically modified mice of TMEM16E

Research Project

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Project/Area Number 23792345
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionHiroshima University

Principal Investigator

MIZUTA Kuniko  広島大学, 大学院・医歯薬保健学研究院(歯), 助教 (40432679)

Project Period (FY) 2011 – 2012
KeywordsTMEM16E / 顎骨骨幹異形成症 / 肢体型筋ジストロフィー / ノックアウトマウス
Research Abstract

In this study, for the purpose of functionalanalysis of TMEM16E gene that is a gene responsible for autosomal recessive limb-girdle muscular dystrophy (LGMD2) and autosomal dominant Gnathodiaphyseal dysplasia (GDD), I performed the physiological function analysis of TMEM16E using TMEM16E knockout mice. Visibly, obvious phenotype was not observed in TMEM16E knockout mice. However we evaluated the systemic organ of adult mice histopathologically and found of ventricular wall thinning and ventricular dilatation. Furthermore, it has been reported that TMEM16A and TMEM16B of TMEM16 family genes have function ascalcium-dependent chloride channel. In TMEM16E stable overexpressing cell line, TMEM16E gene products had no significant chloride channel activity. We showed that TMEM16E has a unique role which is different from the TMEM16 family genes other.

  • Research Products

    (6 results)

All 2012 2011

All Presentation (6 results)

  • [Presentation] Threonine 612 defines the putative poreforming domain character of GDD1/Ano5/TMEM16E2012

    • Author(s)
      Tran TT, Hirono C, Fujimoto S, Mizuta K, Kubozaono K,Sugita M, Kamata N
    • Organizer
      第45回広島大学歯学会総会
    • Place of Presentation
      広島
    • Year and Date
      2012-06-09
  • [Presentation] The tissue specific protein stabilization of GDD1/TMEM16E maintains muscle tissue.2012

    • Author(s)
      Tran TT, Tobiume K, Fujimoto S, Mizuta K, Kubozaono K, Hirono C, Sugita M, Kamata N
    • Organizer
      第66回日本会口腔科学会学術集会
    • Place of Presentation
      広島
    • Year and Date
      2012-05-17
  • [Presentation] Molecular characterization of GDD1/TMEM16E2011

    • Author(s)
      Tran TT, Tobiume K, Fujimoto S, Mizuta K, Hirono C, Sugita M, Kamata N.
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-14
  • [Presentation] Degradation pathway for GDD1/TMEM16E2011

    • Author(s)
      Tran TT, Tobiume K, Fujimoto S, Mizuta K, Hirono C, Sugita M, Kamata N
    • Organizer
      第48回日本口腔組織培養学会学術大会
    • Place of Presentation
      浦安
    • Year and Date
      2011-11-19
  • [Presentation] CaCC activity, localization and stability of TMEM16E2011

    • Author(s)
      Tran TT, Fujimoto S, Mizuta K, Hirono C, Sugita M, Kamata N
    • Organizer
      4th Hiroshima Conference on Education and Science in Dentistry
    • Place of Presentation
      広
    • Year and Date
      2011-10-10
  • [Presentation] CaCC activity, localization, and stability of TMEM16E2011

    • Author(s)
      Ta To Tran,飛梅 圭,藤本伸一,水田邦子,廣野 力,杉田 誠,鎌田伸之
    • Organizer
      第65回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-04-22

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Published: 2014-09-25  

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