2012 Fiscal Year Final Research Report
Development of the molecular target medicine for oral squamous cell carcinoma by the heat shock transcription factor control
| Project/Area Number |
23792349
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Yamaguchi University |
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Principal Investigator |
HORINAGA Daiju 山口大学, 医学部附属病院, 助教 (30379987)
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| Project Period (FY) |
2011 – 2012
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| Keywords | HSF1 |
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| Research Abstract |
I performed effect measurement of an antitumor effect by knockdown in in vitro in CDDP alone using the oral cancer cell, thermotherapy alone, a heat shock transcription factor. I did not significantly accept the reinforcement of the effect in CDDP+KD though I accepted an addition effect in CDDP+HS, HS+KD, but significantly recognized synergy in the tripartite combination group of CDDP+HS+KD. In addition, I knocked down the common gene which caused a drop of the gene expression because knockdown did HSF1 in three kinds of cancer cells strain. Although there was not it, as for the result, as for the cytostasis effect like HSF1, both cytostasis effects were reinforced by the knockdown by the combination.
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