2012 Fiscal Year Final Research Report
Examination of the dendritic cell vaccination in oral cancer adjuvant postoperative treatment
| Project/Area Number |
23792352
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Ehime University |
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Principal Investigator |
TANO Tomoyuki 愛媛大学, 医学部附属病院, 専攻医 (10398026)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 樹状細胞 |
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| Research Abstract |
1. The expression of the genes of Bcl-2 and Bax may be useful prognostic factor in head and neck cancer patients.
2. The possibility that 5-FU may enhance the T cell-stimulatingability of dendritic cells via regulation of the expression of PD-L1 and PD-L2, and that the combination therapy of DC-based cancer vaccine with 5-FU may elicit better anti-tumor efficacy than only vaccination.
3. OK-432-based immunotherapy significantly enhanced therapeutic effects of chemoradiotherapy in patients with oral squamous cell carcinoma, but also elucidating mechanism of synergic effect of the immuno-chemoradiotherapy that 5-FU and radiation enhanced OK-432-induced Th1 response mediated by inhibition of expression of SOCS1 and SOCS3genes.
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[Journal Article] Prognostic impact of expression of bcl-2 and bax genes in circulating immune cells derived from patients with head and neck carcinoma2013
Author(s)
Tano T, Okamoto M, Kan S, Nakashiro K, Shimodaira S, Koido S, Homma S, Sato M, Fujita T, Kawakami Y, Hamakawa H
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Journal Title
Neoplasia.
Volume: 15(3)
Pages: 305-14
Peer Reviewed
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