2013 Fiscal Year Final Research Report
Analysis of T-cell network involved in the pathogenesis and development of oral lichen planus
| Project/Area Number |
23792354
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | サイトカイン / Th1 / Th2 / Th17 / 角化亢進 |
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| Research Abstract |
The expression of Th17 type Th1, Th2 was higher in the OLP patientsIn comparison with healthy subjects, but there was no significant difference about Treg type. IL-17 expression was observed in lymphocytes infiltrated under the epithelium, IL-23 was expression in lymphocytes under the epithelium and all hyperkeratic layers. IL-33 was expressed in the basal layer of mucosa.
From these results, expression of Th17 and Th2 is involved in the pathogenesis of OLP addition to Th1, and that it was indicated that hyperkeratosis was caused by the expression of IL-23.
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[Journal Article] Possible involvement of cytokines, chemokines and chemokine receptors in the initiation and progression of chronic GVHD
Author(s)
Hayashida, J.-N., Nakamura, S., Toyoshima, T., Moriyama, M., Sasaki, M., Kawamura, E., Ohyama, Y., Kumamaru, W., Shirasuna, K
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Journal Title
Bone Marrow Transplant
Volume: 48(1)
Pages: 115-123
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