2012 Fiscal Year Final Research Report
Establishment of peptide vaccine therapy using novel tumor refusal antigens for oral cancer
| Project/Area Number |
23792363
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 腫瘍免疫 / 口腔癌 / 臨床試験 / ペプチドワクチン療法 |
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| Research Abstract |
In our department, there are new patients of oral cancer withmore than 80 people a year. No treatment against sever advanced or recurrent cases, sodevelopment of a new treatment is desired. We therefore prepared three of HLA-restrictedpeptides in the target molecule which are expressed specifically in oral cancer tissue,we have administered peptides vaccine to 43 patients in the past. As a result, it waspossible to reject her tumor completely, and to obtain CR in one case. In most cases,the induction of killer T cells recognizing the peptide was confirmed.
In addition, wecan also confirm of their extended both OS and PFS.
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Research Products
(11 results)
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[Journal Article] CDCA1-derived promiscuous helper epitopes induce CTLs in vitro and invivo: CDCA1-specific CD4+ T-cell immunity augmented by an CTL-epitope vaccine in cancer patients2013
Author(s)
Yusuke Tomita1, Akira Yuno, Hirotake Tsukamoto, Satoru Senju, Sachiko Yoshimura, Ryuji Osawa, Yasuhiro Kuroda, Masatoshi Hirayama, Akinobu Hamada, Hirofumi Jono, Atsushi Irie, Takuya Tsunoda, Hirotsugu Kohrogi, Yoshihiro Yoshitake, Yusuke Nakamura, Masanori Shinohara and Yasuharu Nishimura
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Journal Title
Clinical Cancer Research
Volume: (In press)
Peer Reviewed
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[Journal Article] Selective inhibition of nuclear factor-κB by nuclear factor-κBessential modulator-binding domain peptide suppresses the metastasis of highly metastatic oral squamous cell carcinoma2012
Author(s)
Tanaka T, Nakayama H, Yoshitake Y, IrieA, Nagata M, Kawahara K, Takamune Y,Yoshida R, Nakagawa Y, Ogi H, ShinrikiS, Ota K, Hiraki A, Ikebe T, NishimuraY, Shinohara M
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Journal Title
Cancer Science
Volume: 103(3)
Pages: 455-63
Peer Reviewed
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[Journal Article] Overexpression of cIAP2 contributes to 5-FU resistance and a poor prognosis in oral squamous cell carcinoma2011
Author(s)
Nagata M, Nakayama H, Tanaka T, YoshidaR, Yoshitake Y, Fukuma D, Kawahara K,Nakagawa Y, Ota K, Hiraki A, ShinoharaM
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Journal Title
Br J Cancer
Volume: 105(9)
Pages: 1322-30
Peer Reviewed
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