2012 Fiscal Year Final Research Report
Expression analysis of DKK gene and development of a molecular targeted therapy for oral cancer
| Project/Area Number |
23792365
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
SOGABE Yohei 札幌医科大学, 医学部, 研究員 (50468104)
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| Research Collaborator |
OGI Kazuhiso 札幌医科大学, 医学部, 訪問研究員 (40433114)
HIRATSUKA Hiroyoshi 札幌医科大学, 医学部, 教授 (50165180)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 臨床腫瘍学 / エピジェネティクス |
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| Research Abstract |
In the present study, we examined the relationship between Wnt signaling and epigenetic alteration of the Dickkopf-related protein (DKK) genes in oral squamous cell carcinomas (OSCC). Our result confirms the frequent methylation and silencing of DKK genes in OSCC, and suggest that their loss of function contributes to activation of Wnt signaling that leads to cell proliferation during oral carcinogenesis.
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