2012 Fiscal Year Final Research Report
Development of jaw bone reconstruction material made of osteoconductive titanium fiber mesh scaffold.
| Project/Area Number |
23792366
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Yokohama City University |
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Principal Investigator |
HIROTA Makoto 横浜市立大学, 医学部, 准教授 (20347305)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 口腔顎顔面再建外科学 / 顎骨再建 / チタンファイバースキャホールド |
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| Research Abstract |
The aim of this study was evaluation of the bone regeneration properties of titanium fiber scaffold (TFS) that had been coated with a thin hydroxyapatite (HA) layer. Human osteoblasts culture suggested that the HA coated TFS accelerated osteoblast activity. Reconstructive surgery for rabbit mandibular segmental bone defect using titanium fiber block was performed. The discontinuity of the mandibular bone was completely regenerated by newly formed bone in and on the HA/TFS, suggesting TFS is the materials to reconstruct the jaw bone defects.
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