2012 Fiscal Year Final Research Report
Identification of a new MICA peptide vaccine for oral cancer
| Project/Area Number |
23792371
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 遺伝子多型 / 免疫療法 |
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| Research Abstract |
The purpose of this study was to develop a MICA peptide vaccine. DNA was extracted from the venous blood of consenting patients with oral cancer, and MICA gene microsatellite polymorphism analysis was performed. Examination of serum MICA protein levels revealed a trend of increased MICA protein levels in patients with advanced cancer. While we evaluated various MICA and CD4/CD8 antibodies and attempted to synthesize effective MICA peptides, these efforts were unsuccessful. We plan to carry out studies on γδ T cells, which are involved in cancer immunity, and MICA peptides in the future.
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