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2012 Fiscal Year Final Research Report

Roles of adrenoceptor subtypes in the regulation of accumbal dopaminergic activity

Research Project

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Project/Area Number 23792387
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionNihon University

Principal Investigator

UCHIDA Takuya  日本大学, 歯学部, 助教 (10409104)

Project Period (FY) 2011 – 2012
Keywordsアドレナリン受容体 / カテコラミン / 側坐核 / オーラルジスキネジア
Research Abstract

Oral dyskinesia is a neurological disorder characterized by repetitive stereotyped oral movements. The detailed biological basis of the symptom remains unclear, but behavioural studies suggest that accumbal dopaminergic neurons play a pivotal role in the induction of repetitive jaw movements of rats. It is known that there exists a close noradrenaline?dopamine interaction within this nucleus. In the present study, therefore, we analyzed the role of the adrenoceptor subtypes in the regulation of accumbal noradrenergic and dopaminergic activity in freely moving rats, using the in vivo brain microdialysis technique.

  • Research Products

    (6 results)

All 2012 2011 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] The α1-, but not α2- adrenoceptor in the nucleus accumbens plays an inhibitory role upon the accumbal noradrenaline and dopamine efflux of freely moving rats.2012

    • Author(s)
      Saigusa T, Aono Y, Uchida T, Takada K, Verheij MMM, Koshikawa N, Cools A R.
    • Journal Title

      Eur J Pharmacol

      Volume: 688 Pages: 35-41

    • Peer Reviewed
  • [Journal Article] In vivo neurochemical evidence that newly synthesised GABA activates GABA_B, but not GABA_A, receptors on dopaminergic nerve endings in the nucleus accumbens of freely moving rats.2012

    • Author(s)
      Saigusa T, Aono Y, Sekino R, Uchida T, Takada K, Oi Y, Koshikawa N, Cools AR.
    • Journal Title

      Neuropharmacology

      Volume: 62 Pages: 907-913

    • Peer Reviewed
  • [Journal Article] but notseparate, stimulation of accumbal β1- and β2-adrenoceptors alters the accumbal dopamine efflux in freely moving rats.

    • Author(s)
      Saigusa T, Aono Y, Uchida T, Takada K, Koshikawa N, Cools A R. Synergistic
    • Journal Title

      Eur J Pharmacol

      Volume: (in press)

    • Peer Reviewed
  • [Presentation] Simultaneous, but not separate activation of beta-1?and beta-2?adrenoceptors in the nucleus accumbens increases accumbal dopamine efflux in freely moving rats2012

    • Author(s)
      Uchida T.
    • Organizer
      28th The International College of Neuropsychopharmacology (CINP), Stockholmsmassan
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2012-06-06
  • [Presentation] The alpha-1 adrenoceptor in the nucleus accumbens exerts an inhibitory control upon the accumbal noradrenaline and dopamine efflux in freely moving rats2011

    • Author(s)
      Uchida T.
    • Organizer
      2nd Congress of Asian College ofNeuropsychopharmacology Jointly with 2011Annual Meeting of Korean College ofNeuropsychopharmacology
    • Place of Presentation
      Grand Hilton Seoul Hotel,Seoul, Korea
    • Year and Date
      2011-09-24
  • [Remarks] 研究内容の平易な紹介

    • URL

      http://www.bitway.ne.jp/ejournal/biglobe/2425100899.html

URL: 

Published: 2014-09-25  

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