2012 Fiscal Year Final Research Report
The effects of midazolam and flumazenil on cerebral autoregulation
| Project/Area Number |
23792388
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
OGAWA Yojiro 日本大学, 医学部, 研究員 (60434073)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 脳・神経 / 静脈内鎮静法 / 脳循環 |
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| Research Abstract |
The present study investigated the effects of flumazenil administration after midazolam sedation on cerebral circulation. After flumazenil administration, the augmented cerebral autoregulation due to midazolam sedation did not change. Also, sole administration of flumazenil improved cerebral autoregulation with decreases in cerebral blood flow. These results suggested that flumazenil dose not antagonize the effects of cerebral circulation with midazolam, and induces altered cerebral autoregulation with slight decrease in cerebral blood flow.
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