2012 Fiscal Year Final Research Report
Evaluation of Odz3 function in endochondral ossification and response of mandibular condylar cartilage to mechanical stress.
| Project/Area Number |
23792411
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
NOBUO Takeshita 東北大学, 大学院・歯学研究科, 助教 (50431515)
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| Project Period (FY) |
2011 – 2012
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| Keywords | Odz3 / 内軟骨性骨化 / ATDC5 |
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| Research Abstract |
Most of vertebrate bones are formed by endochondral ossificaiton. However, its molecular mechanisms are not fully understood. In this study, we examined expression and function of Odz3 in ATDC5 to elucidate the roles of Odz3 in endochondral ossification. As a result, expression of Odz3 was down-regulated during chondrogenic differentiation of ATDC5. In addition, expression of Sox9 was induced by knockdown ofOdz3. These results suggest that Odz3 inhibitory regulates chondrogenesis.
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