2012 Fiscal Year Final Research Report
Relationship between mechanical stress-induced CTGF expression and apoptosis in osteocytes.
| Project/Area Number |
23792412
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
HOSHI Kenji 東北大学, 病院, 助教 (90569964)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 歯科矯正学 |
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| Research Abstract |
We examined osteocyte response to mechanical stress focusing on CTGF and apoptosis. Compressive force loading increased CTGF expression, thereafter, apoptosis were induced in osteocytes. Moreover, we demonstrated that CTGF induces osteocyte apoptosis through activation of ERK1/2 pathway. These results, at least in part, revealed the mechanism of bone remodeling regulated by osteocytes under mechanical stress.
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[Journal Article] Differential roles of CCN family proteins during osteoblast differentiation: involvement of Smad and MAPK signaling pathways2011
Author(s)
Harumi Kawaki, Satoshi Kubota, Akiko Suzuki, Makoto Suzuki, Kumiko Kohsaka, Kenji Hoshi, Toshiya Fujii, Noureddine Lazar, Toshihiro Ohgawara, Takeyasu Maeda, Bernard Perbal, Teruko Takano-Yamamoto, Masaharu Takigawa
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Journal Title
Bone
Volume: 49(5)
Pages: 975-89
Peer Reviewed
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