2012 Fiscal Year Final Research Report
Regulation of pathological angiogenesis by estrogen receptors in osteoarthritis
| Project/Area Number |
23792420
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
HOSOMICHI Jun 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (00420258)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 顎関節症 / 関節円板 / 女性ホルモン / 軟骨様関節円板細胞 / 線維芽細胞様関節円板細胞 |
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| Research Abstract |
The purpose of this study was to immortalize and characterize TMJ disc cell clones, and to determinetheir responses to estrogen, relaxin and progesterone. TMJ disc cells from female mice were isolated,and immortalized by human telomerase reverse transcriptase. Clones demonstrating successfulimmortalization were characterized for fibroblast and chondrocyte markers. Chondrocyte-like andfibroblast-like disc clones show different baseline and hormone-stimulated expression profiles of ESRs,RXFPs and MMP9/13.
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