2012 Fiscal Year Final Research Report
Susceptibility for amoxicillin in oral bacteria harbored in the subjects at risk for infective endocarditis
| Project/Area Number |
23792425
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 感染性心内膜炎 / 先天性心疾患 / 術前投与 / アモキシシリン / デンタルプラーク / 耐性菌 |
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| Research Abstract |
The prevalence of amoxicillin-resistant oral streptococcal strains in dental plaque specimens collected from Japanese individuals showed that approximately 5%of the healthy individuals harbored these strains. On the other hand, the detection rate of the subjects at risk for IE was approximately 20%. These amoxicillin-resistant strains tend to be resistant to other antibiotics. The additional large-scale studies regarding the distribution of the amoxicillin-resistant strains in the subject at risk for IE should be required.
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