2013 Fiscal Year Final Research Report
Analysis of Toll-like receptor signaling in Down syndrome with early onset periodontitis
| Project/Area Number |
23792426
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | ダウン症候群 / 歯周炎 / TLR |
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| Research Abstract |
Early onset periodontitis is likely to develop in young persons with Down syndrome. Toll-like receptors(TLR), which initiate key inflammatory responses, and their signaling was investigated in gingival cells derived from persons with Down syndrome. More TLRs and TLR signal molecules are expressed in the cells from Down syndrome than from non-Down syndrome. It seems that overreaction on immune system in Down syndrome is associated with early onset periodontitis.
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