2012 Fiscal Year Final Research Report
Effects of enamel matrix protein on the metabolism of periodontal tissue and application of enamel matrix protein for orthodontic treatment.
| Project/Area Number |
23792428
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
KUNIMATSU Ryo 広島大学, 病院, 歯科診療医 (40580915)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 蛋白質 / 生理活性 / シグナル伝達 / 歯学 / 再生歯学 |
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| Research Abstract |
It is demonstrated that human full-length amelogenin enhances the proliferation of human cementoblasts lineage cells by an interaction with CD63 through MAPK-ERK signaling pathway. In addition, amelogenin up-regulated the expressions of bone specific marker and mineralization activity in the osteogenic differentiation of human cementoblasts. In vivo studies,it is demonstrated that application of amelogenin surely suppresses root resorption. It is thus confirmed that amelogenin may contributeto the regeneration of cementum in terms of the enhancement of human cementoblast lineage cells proliferation and differentiation, indicating an application of amelogenin to regeneration of periodontal tissue.
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Research Products
(13 results)
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[Journal Article] Amelogenin Enhances the Osteogenic Differentiation of Mesenchymal Stem Cells Derived from Bone Marrow2012
Author(s)
Tanimoto K, Huang YC, Tanne Y, Kunimatsu R, Michida M, Yoshioka M, Ozaki N, Sasamoto T, Yoshimi Y, Kato Y, Tanne K
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Journal Title
Cells Tissues Organs
Volume: 196(5)
Pages: 411-9
Peer Reviewed
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[Presentation] バイオミネラリゼーション技術を応用したエナメル質再生法-むし歯進行予防のための新たな戦略2011
Author(s)
國松 亮, 谷本幸太郎, 丹根由起, 神谷貴志, 岩渕泰憲, 吉岡基子, 尾崎徳継, 廣瀬尚人, 笹本智子, 道田将彦, 光吉智美, 吉見友希, 鷲見圭輔, 蘇 少卿, 丹根一夫
Organizer
第70回日本矯正歯科学術大会・第4回国際会議
Place of Presentation
名古屋
Year and Date
20111117-20
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