Elucidation of the role of Osteoactivin in the bone metabolism of the periodontal tissue under the mechanical stress

2015 Fiscal Year Final Research Report

• Project/Area Number: 23792440
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Kyushu Dental College
• Principal Investigator: Kuroishi Kayoko (中尾加代子) 九州歯科大学, 歯学部, 助教 (60468303)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: メカニカルストレス / 歯根膜

Outline of Final Research Achievements

During orthodontic tooth movement, the bone metabolism of periodontal tissue is controlled by periodontal ligament cells. Osteoactivin (OA) was identified as the causative gene in an osteosclerosis rat model, and its osteogenetic role may enable bone formation of a periodontal ligament under tension. The inhibition of bone formation may cause bone resorption on the pressure side as well as the promotion of bone resorption.
In this study, we investigated the possibility that OA activation causes bone formation on the tension side through shedding of OA extracellular domain by ADAM12 and ADAM17. We also examined whether the expression and release of bone formation inhibitory factors as Asporin or SOST/sclerostin inhibited bone formation on the pressure side under either optimal or weak orthodontic forces

Free Research Field

歯科矯正学