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2013 Fiscal Year Final Research Report

The effects of masticated alteration on brain and aging

Research Project

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Project/Area Number 23792444
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthodontic/Pediatric dentistry
Research InstitutionShowa University

Principal Investigator

ENOMOTO AKIKO  昭和大学, 歯学部, 普通研究生 (60514982)

Project Period (FY) 2011 – 2013
Keywords脳機能 / 咀嚼 / 老化 / 行動解析 / 遺伝子発現
Research Abstract

Mastication is one of the most important oral functions, and the period during which mastication is acquired overlaps with the term of rapid development and maturation of the neural systems. However, the roles of mastication during this period for brain development remain largely unknown.
Therefore, we used a series of standard behavioral analyses, assessment of hippocampal cell proliferation, and the gene expression analysis of mice to investigate the effects of post-weaning mastication on brain function. Compared to mice fed a hard diet (HDM), soft-diet mice (SDM) showed behavioral impairment in prepulse inhibition, significantly decreased hippocampal cell proliferation and brain-derived neurotrophic factor(BDNF) gene expression. These results were similar to those observed in mouse models of schizophrenia. A soft diet after weaning may have resulted in histological and molecular changes in the hippocampus and influenced outcomes of behavioral tests related to mental disorders.

  • Research Products

    (6 results)

All 2014 2012

All Journal Article (1 results) Presentation (5 results)

  • [Journal Article] Soft-diet feeding after weaning affects behavior in mice, potential increase in vulnerability to mental disorders2014

    • Author(s)
      Nose-Ishibashi K, Watahiki J, Yamada K, Maekawa M, Watanabe A, Yamamoto G, Enomoto A, Matsuba Y, Nampo T, Taguchi T, Ichikawa Y, Saido TC, Mishima K, Yamaguchi Y, Yoshikawa T, Maki K
    • Journal Title

      Neuroscience

      Volume: 263(Accepted) Pages: 257-268

  • [Presentation] Soft-diet feeding immediately after weaning results in a defi cit of prepulse inhibition and causes changes in the gene expression profi le in the brain of mice2012

    • Author(s)
      Junichi Watahiki, Kana Nose,Tomohiro Taguchi,Gou Yamamoto,Akiko Enomoto, Kazuyuki Yamada, Motoko Maekawa,Tomoki Nampo,Yuta Ichikawa,Miki Ono,Kenji Mishima,Takeo Yoshikawa,Koutaro Maki
    • Organizer
      第35回日本神経科学学会
    • Year and Date
      20120918-21
  • [Presentation] 成長発育期の軟食と精神疾患発症との関連性について(第二報)2012

    • Author(s)
      野瀬佳奈, 綿引淳一, 山本剛, 市川雄大, 山田一之, 前川素子, 榎本明子, 南保友樹, 田口智博, 小野美樹, 美島健二, 吉川武男, 槇宏太郎
    • Organizer
      第71回日本矯正歯科学会学術大会プログラム抄録集
    • Year and Date
      20120000
  • [Presentation] 離乳時からの軟食は精神疾患の発症リスクを高める可能性がある2012

    • Author(s)
      野瀬佳奈, 綿引淳一, 山本剛, 市川雄大, 前川素子, 榎本明子, 南保友樹, 美島健二, 吉川武男, 槇宏太郎
    • Organizer
      第54回歯科基礎医学会学術大会学術集会プログラム抄録集
    • Year and Date
      20120000
  • [Presentation] Soft-diet feeding during development may increase vulnerability to mental disorders in mice2012

    • Author(s)
      Kana Ishibashi-Nose, Junichi Watahiki, Gou Yamamoto, Kazuyuki Yamada, Yuta Ichikawa, Motoko Maekawa, Akiko Enomoto, Tomoki Nampo, Tomohiro Taguchi, Miki Ono, Takeo Yoshikawa, Koutaro Maki
    • Organizer
      Dental Medicine Research
    • Year and Date
      20120000
  • [Presentation] Influence of Soft-diet Feeding on Hippocampal Neurogenesis in Young Mice after Weaning2012

    • Author(s)
      Kana Ishibashi-Nose, Junichi Watahiki, Motoko Maekawa, Akiko Watanabe, Akiko Enomoto, Tomoki Nanpo, Tomohiro Taguchi, Yuta Ichikawa, Miki Ono, Koutaro Maki
    • Organizer
      Dental Medicine Research
    • Year and Date
      20120000

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Published: 2015-06-25  

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