2012 Fiscal Year Final Research Report
The development of a new route of administration to relieve the side effects of Bisphosphonates.
| Project/Area Number |
23792454
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | ビスフォスフォネート / マウスモデル / イオントフォレシス / 顎骨壊死 |
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| Research Abstract |
Bisphosphonates (BPs) have powerful anti- bone-resorptive effects. However, BPs are known to have several undesirable side effects (such as influenzalike fever, gastrointestinal disturbance). Iontophoresis is the one of the electrical methods that have been employed to enhance drug transportation across the skin. Transdermal drug delivery has a number of potential advantages compared with conventional methods: painless, no degradation from passage through the gastrointestinal tract or the liver. BPs were successfully transportedthrough living mouse skin in a dose-, voltage-, and time-dependent manner.
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