2012 Fiscal Year Final Research Report
INDUCTION OF DC-SIGN-MEDIATED CROSS-PRIMING BY PERIODONTAL PATHOGENS
| Project/Area Number |
23792464
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontal dentistry
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| Research Institution | Ohu University (2012)
Tohoku University (2011) |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 慢性歯周炎 / 樹状細胞 / サイトカイン / クロスプライミング |
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| Research Abstract |
We examined the induction of DC-mediated cross-priming upon Porphyromonas gingivalis (P. g) stimulation in vitro. The stimulation of DCs with P. ginduced the upregulation of Ag cross-presentation and of CD86. The enhancement of DC-mediated cross-priming by P. g was suppressed upon co-stimulation with P. g-derived fimbriae. These results may suggest that P. g could evade the induction of DC-mediated cross-priming.
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Research Products
(11 results)
