2012 Fiscal Year Final Research Report
Effects of the Neutrophil Elastase on periodontal ligament cells and the clinical application of Neutrophil Elastase inhibitor to periodontal disease.
| Project/Area Number |
23792489
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontal dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
UJIIE Yuko 鶴見大学, 歯学部, 助教 (60588599)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 歯周予防学 |
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| Research Abstract |
It is known that Neutrophil Elastase is one of the neutral proteinase and it degrade foreign objects at the inflammatory situation. The proteinase increased in the periodontal ligament which supports teeth, and it degraded non-collagenous matrix of periodontal ligaments. At this experiment, we demonstrated that the neutrophil elastase related with the degradation of periodontal ligament and bone matrix. Additionally, we implied a possibility that the inhibitor of neutrophil elastase restrained the differentiation of osteoclasts, moreover, the inhibitor suppressed a degradation of periodontal ligaments.
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