2013 Fiscal Year Final Research Report
A role of serum amyloid A in atherosclerosis onset.
| Project/Area Number |
23792491
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontal dentistry
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| Research Institution | Aichi Gakuin University (2012-2013)
Matsumoto Dental University (2011) |
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Principal Investigator |
NISHIDA Eisaku 愛知学院大学, 歯学部, 非常勤講師 (10512519)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 歯周病 / 動脈硬化症 / 血管内皮細胞 / 単球遊走因子 / 単球接着因子 |
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| Research Abstract |
Periodontitis is a local inflammatory disease, and it has been reported that this disease might affect the onset of atherosclerosis. Recently, it has been reported that the injection of IL-6 to the periodontal tissue increased mRNA level in the liver and the protein level in the peripheral blood of serum amyloid A (SAA) in C57BL/6J mice before. SAA is an acute phase protein that affects for the systemic inflammation. Therefore, we tried to examine whether SAA could be a marker of atherosclerogenesis in vitro (human aortic endothelial cells: HAEC) or not. After the induction of SAA protein in HAEC, adhesion molecules were expressed significantly. So, a state of the high concentration SAA presence to continue in peripheral blood was suggested the possibility of developing atherosclerosis.
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