2012 Fiscal Year Final Research Report
Elucidation of the blood vessel calcification mechanism due to periodontal disease
| Project/Area Number |
23792492
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontal dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
MUTO Akinori 松本歯科大学, 歯学部, 助教 (50549433)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 歯周病 / 血管の石灰化 / RANK / ペリオドンタルメディスン |
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| Research Abstract |
The calcification of the blood vessel becomes the risk factor by the resistant increase of the blood vessel. Therefore, I started research on the mechanism of the calcification of the blood vessel through periodontal disease in this study. In the periodontal disease inductivity blood vessel calcification model (IL-6 injected to intraoral), atherosclerotic plaque was increased in the IL-6 administrated group. In addition, the calcified degree of the blood vessel was high in the IL-6 administrated group. Furthermore, I performed of the influence on calcification by the inflammatory cytokine (IL-6) addition in human aorta vascular smooth muscle cell (HUVEC). As a result, expression of ALP and RANKL were increased, but the expression of MGP which was a calcified inhibitor did not increase. Therefore, these results suggested that increasing of periodontal disease inductivity cytokines were involved in the calcification of the blood vessel. In future, this study may contributes to elu idation of mechanism in the calcification of arteriosclerosis due to periodontal disease and it will be elucidated in the relation with periodontal disease and calcification of the blood vessel.
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[Journal Article] Tetracyclines convert the osteoclastic- differentiation pathway of progenitor cells to produce dendritic cell-like cells.2012
Author(s)
Kinugawa S, Koide M, Kobayashi Y, Mizoguchi T, Ninomiya T, Muto A, Kawahawa I, Nakamura M, Yasuda H, Takahashi N, Udagawa N.
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Journal Title
J Immunol
Volume: 188
Pages: 1772-1781
DOI
Peer Reviewed
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[Journal Article] 歯肉メラニン色素沈着症に対する歯科用(Er:YAG, Co2)レーザーの着色除去効果2012
Author(s)
西田英作, 三木 学, 武藤 昭紀, 窪川恵太, 片瀬剛士, 内田啓一, 阪中孝一郎,大原盛勝, 大野友三, 吉成伸夫
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Journal Title
日レ歯誌
Volume: 23
Pages: 27-32
Peer Reviewed
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[Journal Article] Lineage-committed osteoclast precursors circulate in blood and settle down into bone.2011
Author(s)
Muto A,Mizoguchi T, Udagawa N, Ito S, Kawahawa I, Abiko A, Harada S, Kobayashi Y, Nakamichi Y, Penninger JM, Noguchi T, Takahashi N.
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Journal Title
J Bone Miner Res
Volume: 26
Pages: 2978-2990
DOI
Peer Reviewed
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