2013 Fiscal Year Final Research Report
Analysis study for wound healing process of oral mucositis
| Project/Area Number |
23792496
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Social dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 口内炎 / 創傷治癒 / 抗がん剤 / 分子生物学 |
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| Research Abstract |
We researched the effect of medication reducing or prohibiting oral mucositis, which is one of severe side effect of chemotherapy and radiotherapy for cancer. It was saying that Hangeshashintou, TJ14 has effect for oral mucositis clinically. Our research indicated this medication inhibited the exacerbation of oral mucositis during radiotherapy for head and neck cancer. We also investigated the pharmacological action of Hangeshashintou by TR146, oral epithelial cell line, culture system. Cell proliferation was increasing on dose-dependent manner. On the other hand, migration assay indicated that Hangeshashintou prohibited cell migration on dose-dependent manner.
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