2013 Fiscal Year Final Research Report

Association between Helicobacter pylori infection with atrophic gastritis and lifestyle: a general population-based cohort study

Research Project

Project/Area Number	23792684
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Community health/Gerontological nurisng
Research Institution	Hirosaki University
Principal Investigator	KURAUCHI Shizuka 弘前大学, 保健学研究科, 助教 (60455730)
Project Period (FY)	2011 – 2013
Keywords	ヘリコバクター・ピロリ感染 / 萎縮性胃炎 / 生活習慣
Research Abstract	An association between incidence of stomach cancer and Helicobacter pylori (Hp)-induced atrophic gastritis (AG) has been reported in a number of previous studies. In this Japanese general population-based study, we examined the relationship between Hp infection with AG and lifestyle. Subjects included participants from a health promotion project who were infected with Hp without AG in 2007 (n=41). They were divided into the maintenance group (AG(-), n=35) and the progression group (AG(+), n=6) according to the AG state in 2012. In many maintenance group, there were many subjects who underwent with eradication therapy of Hp, which could prevent progression of AG. No significant differences were seen between groups in lifestyle data; however, significant differences were evident in dietary intake of milk and fish with less fat in the previous month. Relationships between food and mucosal atrophy should be examined for gastric cancer prevention.