Spatial-temporal structure of synaptic inputs-large-scale spine imaging study-

2011 Fiscal Year Final Research Report

• Project/Area Number: 23800019
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Neurophysiology and muscle physiology
• Research Institution: The University of Tokyo
• Principal Investigator: TAKAHASHI Naoya 東京大学, 大学院・薬学系研究科, 助教 (80609842)
• Research Collaborator: KITAMURA Kazuo 東京大学, 大学院・医学系研究科, 准教授 (60423159) ; MATSUO Naoki 京都大学, 白眉センター, 准教授 (10508956) ; KANO Masanobu 東京大学, 大学院・医学系研究科, 教授 (40185963) ; MATSUKI Norio 東京大学, 大学院・薬学系研究科, 教授 (70126168) ; IKEGAYA Yuji 東京大学, 大学院・薬学系研究科, 准教授 (10302613)
• Project Period (FY): 2011
• Keywords: 神経科学 / 脳・神経

Research Abstract

To reveal the spatial geometry of synaptic inputs on dendrites, we optically imaged synaptic activities from hundreds of dendritic spines in hippocampal CA3 pyramidal cells. When a neuron received synchronous synaptic inputs, the coactivated spines tended to be located closely within～10μm along the dendrites. In contrast, synchronous inputs were dispersed over dendrites of fast-spiking basket cells, a subclass of inhibitory interneurons in CA3. Thus, spatial integration of synaptic inputs is cell-type specific.

Research Products

• [Journal Article] Locally synchronized synaptic inputs (2012)
  • Author(s): Takahashi N, Kitamura K, Matsuo N, Mayford M, Kano M, Matsuki N, Ikegaya Y
  • Journal Title: Science Volume: 335 Pages: 353-6
  • Peer Reviewed
• [Presentation] Locally Synchronized Dendritic Inputs in Hippocampal Pyramidal Cells (2012)
  • Author(s): Takahashi N, Matsuki N, Ikegaya Y
  • Organizer: 8^<th> FENS Forum of Neuroscience
  • Place of Presentation: バルセロナ
  • Year and Date: 20120700
• [Presentation] Clustered synaptic inputs onto local dendrites : a large-scale spine imaging study (2011)
  • Author(s): Takahashi N, Matsuki N, Ikegaya Y
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 20110900