2012 Fiscal Year Final Research Report
Potential role of lactate in exercise-induced mitochondrial biogenesis
| Project/Area Number |
23800021
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Sports science
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
HOSHINO Daisuke 東京大学, 大学院・総合文化研究科, 助教 (70612117)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | 乳酸 / ミトコンドリア / 骨格筋 / 運動 |
|---|
| Research Abstract |
We examined whether lactate accumulation associate with exercise-induced mitochondrial biogenesis. We found that dichloroacetate (DCA) injection can decrease muscle and plasma lactate concentration during exercise. DCA injection and exercise were performed in mice for 4 weeks. As a result, the decrease in lactate accumulation by DCA administration attenuated increases in mitochondrial proteins with exercise training. This result suggests that lactate can be a signal for exercise-induced mitochondrial biogenesis in skeletal muscle.
|
